Nna1 Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Belongs to the peptidase M14 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.17.-; Protease
Chromosomal Location of Human Ortholog: 13 B2|13 31.87 cM
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleolus; nucleus
Molecular Function:  carboxypeptidase activity; hydrolase activity; metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; protein binding; tubulin binding; zinc ion binding
Biological Process:  adult walking behavior; C-terminal protein deglutamylation; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; eye photoreceptor cell differentiation; mitochondrion organization; neuromuscular process; neurotransmitter metabolic process; olfactory bulb development; protein side chain deglutamylation; proteolysis; retina development in camera-type eye
Reference #:  Q641K1 (UniProtKB)
Alt. Names/Synonyms: 1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik; Agtpbp1; atms; ATP/GTP binding protein 1; ATP/GTP-binding protein 1; BB114605; CBPC1; Ccp; Ccp1; Cytosolic carboxypeptidase 1; MGC90651; mKIAA1035; Nervous system nuclear protein induced by axotomy; Nervous system nuclear protein induced by axotomy protein 1; nmf243; Nna1; nuclear ATP/GTP-binding protein; pcd; Purkinje cell degeneration
Gene Symbols: Agtpbp1
Molecular weight: 137,197 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene