ZNF609
Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis. Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: C2H2-type zinc finger protein |
Chromosomal Location of mouse Ortholog: 9|9 C |
Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
metal ion binding; promoter-specific chromatin binding; protein binding
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Biological Process:
multicellular organism development; muscle organ development; positive regulation of neuron migration; positive regulation of T cell differentiation in thymus; positive regulation of transcription by RNA polymerase II; regulation of myoblast proliferation; regulation of transcription by RNA polymerase II
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Reference #:
Q8BZ47
(UniProtKB)
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Alt. Names/Synonyms: 9830165N24; BC016271; Kiaa0295; mKIAA0295; Zfp609; Zinc finger protein 609; ZN609; Znf609
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Gene Symbols: Znf609
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Molecular weight:
151,117 Da
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Basal Isoelectric point:
8.23
Predict pI for various phosphorylation states
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