ZNF609 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis. Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 9|9 C
Cellular Component:  integrator complex; nucleoplasm; nucleus
Molecular Function:  metal ion binding; nucleic acid binding; protein binding
Biological Process:  multicellular organism development; muscle organ development; positive regulation of neuron migration; positive regulation of T cell differentiation in thymus; positive regulation of transcription by RNA polymerase II; regulation of myoblast proliferation; regulation of transcription by RNA polymerase II
Reference #:  Q8BZ47 (UniProtKB)
Alt. Names/Synonyms: 9830165N24; BC016271; Kiaa0295; mKIAA0295; Zfp609; Zinc finger protein 609; ZN609; Znf609
Gene Symbols: Znf609
Molecular weight: 151,117 Da
Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene