UBN1 Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Belongs to the ubinuclein family. Ubiquitous. Also expressed in numerous tumors and cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 16 A1|16 2.49 cM
Cellular Component:  bicellular tight junction; cell junction; centriolar satellite; nuclear body; nucleoplasm; nucleus
Molecular Function:  DNA binding; transcription factor binding
Biological Process:  chromatin organization; keratinocyte differentiation; nucleosome assembly
Reference #:  Q4G0F8 (UniProtKB)
Alt. Names/Synonyms: 1110029L11Rik; 2610108L02Rik; AA673476; AW124741; MGC102206; ubinuclein 1; Ubinuclein-1; Ubiquitously expressed nuclear protein; Ubn1
Gene Symbols: Ubn1
Molecular weight: 122,336 Da
Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states
Select Structure to View Below

UBN1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene