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UBN1
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Belongs to the ubinuclein family. Ubiquitous. Also expressed in numerous tumors and cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of mouse Ortholog: 16 A1|16 2.49 cM |
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Cellular Component:
bicellular tight junction; cell junction; centriolar satellite; nuclear body; nucleoplasm; nucleus
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Molecular Function:
DNA binding; transcription factor binding
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Biological Process:
chromatin organization; keratinocyte differentiation; nucleosome assembly
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Reference #:
Q4G0F8
(UniProtKB)
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Alt. Names/Synonyms: 1110029L11Rik; 2610108L02Rik; AA673476; AW124741; MGC102206; ubinuclein 1; Ubinuclein-1; Ubiquitously expressed nuclear protein; Ubn1
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Gene Symbols: Ubn1
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Molecular weight:
122,336 Da
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Basal Isoelectric point:
9.35
Predict pI for various phosphorylation states
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