RNF138 E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 18|18 A2
Cellular Component:  chromosome; site of double-strand break
Molecular Function:  DNA binding; metal ion binding; protein kinase binding; single-stranded DNA binding; transferase activity; ubiquitin protein ligase activity
Biological Process:  cellular response to DNA damage stimulus; cellular response to leukemia inhibitory factor; DNA double-strand break processing involved in repair via single-strand annealing; DNA repair; double-strand break repair via homologous recombination; protein ubiquitination; Wnt signaling pathway
Reference #:  Q9CQE0 (UniProtKB)
Alt. Names/Synonyms: 2410015A17Rik; 2810480D20Rik; E3 ubiquitin-protein ligase RNF138; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138; RN138; Rnf138; STRIN; Trif; Trif-d
Gene Symbols: Rnf138
Molecular weight: 28,299 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene