FILIP1 By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. Belongs to the FILIP1 family. Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 9|9 E1
Cellular Component:  actin cytoskeleton; cytoplasm; cytoskeleton; glutamatergic synapse; nucleolus; plasma membrane; postsynaptic actin cytoskeleton
Biological Process:  modification of postsynaptic structure
Reference #:  Q9CS72 (UniProtKB)
Alt. Names/Synonyms: 5730485H21Rik; AI843021; filamin A interacting protein 1; Filamin-A-interacting protein 1; FILIP; Filip1; FLIP1
Gene Symbols: Filip1
Molecular weight: 137,599 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene