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quiescin Q6
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.8.3.2; Membrane protein, integral; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 1|1 G3 |
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Cellular Component:
endoplasmic reticulum; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; intercellular bridge; intracellular membrane-bounded organelle; membrane
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Molecular Function:
FAD binding; flavin-dependent sulfhydryl oxidase activity; oxidoreductase activity; protein disulfide isomerase activity; thiol oxidase activity
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Biological Process:
extracellular matrix assembly; negative regulation of macroautophagy; protein folding
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Reference #:
Q8BND5
(UniProtKB)
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Alt. Names/Synonyms: 1300003H02Rik; b2b2673C; b2b2673Clo; mSOx; OTTMUSP00000030862; Qsc; Qscn6; QSOX; Qsox1; Quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; Skin sulfhydryl oxidase; Sox; Sulfhydryl oxidase 1
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Gene Symbols: Qsox1
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Molecular weight:
82,785 Da
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Basal Isoelectric point:
6.73
Predict pI for various phosphorylation states
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