quiescin Q6 Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Oxidoreductase
Chromosomal Location of mouse Ortholog: 1|1 G3
Cellular Component:  endoplasmic reticulum; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; integral component of Golgi membrane; integral component of membrane; intercellular bridge; intracellular membrane-bounded organelle; membrane
Molecular Function:  FAD binding; flavin-linked sulfhydryl oxidase activity; oxidoreductase activity; protein disulfide isomerase activity; thiol oxidase activity
Biological Process:  cell redox homeostasis; extracellular matrix assembly; negative regulation of macroautophagy; oxidation-reduction process
Reference #:  Q8BND5 (UniProtKB)
Alt. Names/Synonyms: 1300003H02Rik; b2b2673C; b2b2673Clo; mSOx; OTTMUSP00000030862; Qsc; Qscn6; QSOX; Qsox1; Quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; Skin sulfhydryl oxidase; Sox; Sulfhydryl oxidase 1
Gene Symbols: Qsox1
Molecular weight: 82,785 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below

quiescin Q6

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene