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HEFL
Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. Belongs to the CAS family. Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 2|2 H3 |
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Cellular Component:
anchoring junction; cytoplasm; cytoskeleton; focal adhesion; plasma membrane
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Molecular Function:
protein tyrosine kinase binding
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Biological Process:
cell adhesion; cell migration; positive regulation of cell migration; positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; positive regulation of substrate adhesion-dependent cell spreading; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q08EC4
(UniProtKB)
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Alt. Names/Synonyms: Cas scaffolding protein family member 4; Cass4; F730031O20Rik; HEF-like protein; HEFL; likely orthologue of H. sapiens chromosome 20 open reading frame 32 (C20orf32); OTTMUSP00000017288
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Gene Symbols: Cass4
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Molecular weight:
88,621 Da
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Basal Isoelectric point:
6.63
Predict pI for various phosphorylation states
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