CTCF a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  chromosome, centromeric region; condensed chromosome; nucleolus; nucleoplasm; nucleus
Molecular Function:  chromatin insulator sequence binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  chromosome segregation; DNA methylation; maintenance of DNA methylation; negative regulation of cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nucleosome positioning; positive regulation of gene expression; positive regulation of transcription, DNA-templated; protein localization to chromosome, centromeric region; regulation of centromeric sister chromatid cohesion; regulation of gene expression by genetic imprinting; regulation of gene expression, epigenetic; regulation of histone acetylation; regulation of histone methylation; regulation of molecular function, epigenetic
Disease: Mental Retardation, Autosomal Dominant 21
Reference #:  P49711 (UniProtKB)
Alt. Names/Synonyms: 11 zinc finger transcriptional repressor; 11-zinc finger protein; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCF; CTCFL paralog; Transcriptional repressor CTCF
Gene Symbols: CTCF
Molecular weight: 82,785 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene