HYAL4 Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. Belongs to the glycosyl hydrolase 56 family. Detected in placenta and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 6|6 A3.1
Cellular Component:  cell surface; cytoplasmic vesicle; lysosome; membrane
Molecular Function:  chondroitin hydrolase activity; hyalurononglucosaminidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds
Biological Process:  carbohydrate metabolic process; chondroitin sulfate catabolic process; hyaluronan catabolic process; metabolic process
Reference #:  Q05A56 (UniProtKB)
Alt. Names/Synonyms: 4632428M18Rik; Chondroitin sulfate endo-beta-N-acetylgalactosaminidase; Chondroitin sulfate hydrolase; CSHY; Hyal-4; Hyal4; Hyaluronidase-4; hyaluronoglucosaminidase 4; Hyaluronoglucosaminidase-4
Gene Symbols: Hyal4
Molecular weight: 54,385 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein