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ETAA16
Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface |
| Chromosomal Location of Human Ortholog: 11|11 A3.1 |
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Cellular Component:
nuclear replication fork; nucleus
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Molecular Function:
protein serine/threonine kinase activator activity
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Biological Process:
cellular response to DNA damage stimulus; DNA repair; positive regulation of protein serine/threonine kinase activity; regulation of DNA damage checkpoint; replication fork processing
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Reference #:
Q5SVT3
(UniProtKB)
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Alt. Names/Synonyms: 5730466H23Rik; AA672646; Etaa1; ETAA16; Ewing tumor-associated antigen 1; Ewing's tumor-associated antigen 1; Ewing's tumor-associated antigen 1 homolog; OTTMUSP00000005400
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Gene Symbols: Etaa1
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Molecular weight:
96,552 Da
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Basal Isoelectric point:
8.59
Predict pI for various phosphorylation states
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