ETAA16 Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 11|11 A3.1
Cellular Component:  nuclear replication fork; nucleus
Molecular Function:  protein serine/threonine kinase activator activity
Biological Process:  cellular response to DNA damage stimulus; DNA repair; positive regulation of protein serine/threonine kinase activity; regulation of DNA damage checkpoint; replication fork processing
Reference #:  Q5SVT3 (UniProtKB)
Alt. Names/Synonyms: 5730466H23Rik; AA672646; Etaa1; ETAA16; Ewing tumor-associated antigen 1; Ewing's tumor-associated antigen 1; Ewing's tumor-associated antigen 1 homolog; OTTMUSP00000005400
Gene Symbols: Etaa1
Molecular weight: 96,552 Da
Basal Isoelectric point: 8.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene