GIT1 iso3 GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  calyx of Held; cytosol; focal adhesion
Molecular Function:  GTPase activator activity; metal ion binding; protein binding; protein-containing complex binding
Biological Process:  ephrin receptor signaling pathway; positive regulation of GTPase activity; presynaptic modulation of chemical synaptic transmission; regulation of cytokinesis; regulation of G protein-coupled receptor signaling pathway; regulation of synaptic vesicle exocytosis
Reference #:  Q9Y2X7-3 (UniProtKB)
Alt. Names/Synonyms: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase interactor 1 variant; G protein-coupled receptor kinase-interactor 1; GIT ArfGAP 1; GIT1; GIT1 iso3; GRK-interacting protein 1
Gene Symbols: GIT1
Molecular weight: 85,446 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

GIT1 iso3

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene