SFRS6 Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. Belongs to the splicing factor SR family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 2 H2|2 83.87 cM
Cellular Component:  nuclear speck; nucleus
Molecular Function:  nucleic acid binding; pre-mRNA binding; protein binding; RNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; mRNA processing; mRNA splice site selection; negative regulation of cell death; negative regulation of gene expression; negative regulation of keratinocyte differentiation; negative regulation of mRNA splicing, via spliceosome; negative regulation of type B pancreatic cell apoptotic process; positive regulation of epithelial cell proliferation involved in lung morphogenesis; regulation of alternative mRNA splicing, via spliceosome; regulation of keratinocyte proliferation; regulation of wound healing; RNA splicing
Reference #:  Q3TWW8 (UniProtKB)
Alt. Names/Synonyms: 1210001E11Rik; AI314910; arginine/serine-rich splicing factor 6; AW146126; OTTMUSP00000001014; Pre-mRNA-splicing factor SRP55; serine and arginine-rich splicing factor 6; Serine/arginine-rich splicing factor 6; Sfrs6; splicing factor, arginine/serine-rich 6; Srp55; SRSF6
Gene Symbols: Srsf6
Molecular weight: 39,025 Da
Basal Isoelectric point: 11.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein