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SFRS6
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. Belongs to the splicing factor SR family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 2 H2|2 83.87 cM |
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Cellular Component:
cytoplasm; nuclear speck; nucleus; ribonucleoprotein complex
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Molecular Function:
mRNA binding; nucleic acid binding; pre-mRNA binding; protein binding; RNA binding
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Biological Process:
alternative mRNA splicing, via spliceosome; mRNA processing; mRNA splice site recognition; negative regulation of gene expression; negative regulation of keratinocyte differentiation; negative regulation of mRNA splicing, via spliceosome; negative regulation of type B pancreatic cell apoptotic process; positive regulation of epithelial cell proliferation involved in lung morphogenesis; regulation of alternative mRNA splicing, via spliceosome; regulation of keratinocyte proliferation; regulation of wound healing; RNA splicing
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Reference #:
Q3TWW8
(UniProtKB)
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Alt. Names/Synonyms: 1210001E11Rik; AI314910; arginine/serine-rich splicing factor 6; AW146126; OTTMUSP00000001014; Pre-mRNA-splicing factor SRP55; serine and arginine-rich splicing factor 6; Serine/arginine-rich splicing factor 6; Sfrs6; splicing factor, arginine/serine-rich 6; Srp55; SRSF6
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Gene Symbols: Srsf6
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Molecular weight:
39,025 Da
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Basal Isoelectric point:
11.46
Predict pI for various phosphorylation states
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