CDK12
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome
Molecular Function: ATP binding; cyclin binding; kinase activity; nucleotide binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity
Biological Process: mRNA processing; negative regulation of stem cell differentiation; phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; protein phosphorylation; regulation of MAP kinase activity; regulation of RNA splicing; RNA splicing; transcription by RNA polymerase II
