dUTPase This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Belongs to the dUTPase family. Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC 3.6.1.23; Hydrolase; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine
Chromosomal Location of mouse Ortholog: 2 F1|2 61.33 cM
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  dUTP diphosphatase activity; hydrolase activity; identical protein binding; magnesium ion binding; metal ion binding; peroxisome proliferator activated receptor binding; pyrimidine deoxyribonucleotide binding; signaling receptor inhibitor activity
Biological Process:  dTMP biosynthetic process; dUMP biosynthetic process; dUTP catabolic process; nucleotide metabolic process; regulation of protein-containing complex assembly
Reference #:  Q9CQ43 (UniProtKB)
Alt. Names/Synonyms: 5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Deoxyuridine 5'-triphosphate nucleotidohydrolase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; Deoxyuridine triphosphatase; Deoxyuridine triphosphatase, isoform CRA_b; Dut; Dutp; Dutp protein; dUTP pyrophosphatase; dUTPase; OTTMUSP00000016348
Gene Symbols: Dut
Molecular weight: 17,385 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
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dUTPase

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein