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LZK
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of mouse Ortholog: 16|16 B1 |
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Cellular Component:
cytoplasm; membrane
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Molecular Function:
ATP binding; enzyme binding; identical protein binding; IkappaB kinase complex binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
JNK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of axon extension; positive regulation of branching morphogenesis of a nerve; positive regulation of JUN kinase activity; positive regulation of neuron maturation; positive regulation of neuron projection arborization; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase activity; protein autophosphorylation; protein phosphorylation; stress-activated MAPK cascade
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Reference #:
Q1HKZ5
(UniProtKB)
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Alt. Names/Synonyms: C130026N12Rik; LZK; M3K13; Map3k13; mitogen activated protein kinase kinase kinase 13; Mitogen-activated protein kinase kinase kinase 13
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Gene Symbols: Map3k13
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Molecular weight:
106,987 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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SAPK/JNK Signaling Cascades
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