LZK Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of mouse Ortholog: 16|16 B1
Cellular Component:  cytoplasm; membrane
Molecular Function:  ATP binding; enzyme binding; identical protein binding; IkappaB kinase complex binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of JNKK activity; activation of JUN kinase activity; activation of MAPKK activity; JNK cascade; MAPK cascade; peptidyl-serine phosphorylation; phosphorylation; positive regulation of axon extension; positive regulation of branching morphogenesis of a nerve; positive regulation of neuron maturation; positive regulation of neuron projection arborization; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation
Reference #:  Q1HKZ5 (UniProtKB)
Alt. Names/Synonyms: C130026N12Rik; LZK; M3K13; Map3k13; mitogen activated protein kinase kinase kinase 13; Mitogen-activated protein kinase kinase kinase 13
Gene Symbols: Map3k13
Molecular weight: 106,987 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades
Select Structure to View Below

LZK

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene