|
K6IRS3
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Belongs to the intermediate filament family. Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 15|15 F2 |
|
Cellular Component:
intermediate filament; keratin filament
|
|
Molecular Function:
structural constituent of skin epidermis
|
|
Biological Process:
intermediate filament organization; keratinization
|
|
Reference #:
Q6NXH9
(UniProtKB)
|
|
Alt. Names/Synonyms: BC067067; CK-73; Cytokeratin-73; K2C73; K6IRS3; K73; Kb36; keratin 73; Keratin, type II cytoskeletal 73; Keratin-73; Krt73; Type II inner root sheath-specific keratin-K6irs3; type II keratin Kb36; Type-II keratin Kb36
|
|
Gene Symbols: Krt73
|
|
Molecular weight:
58,911 Da
|
|
Basal Isoelectric point:
8.36
Predict pI for various phosphorylation states
|
