CENTG3 GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Belongs to the centaurin gamma-like family. Widely expressed. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF
Chromosomal Location of Human Ortholog: 5|5 A3
Cellular Component:  cell periphery; cytoplasm; membrane; nucleus; PML body
Molecular Function:  GTP binding; GTPase activator activity; GTPase activity; metal ion binding; nucleotide binding; polyubiquitin modification-dependent protein binding
Biological Process:  cellular response to reactive oxygen species; cellular response to UV; PML body organization; proteasome-mediated ubiquitin-dependent protein catabolic process; protein import into nucleus; signal transduction
Reference #:  Q8VHH5 (UniProtKB)
Alt. Names/Synonyms: AGAP-3; Agap3; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; AV028425; centaurin, gamma 3; Centaurin-gamma-3; Centg3; Cnt-g3; CRAG; CRAM-associated GTPase; MGC37541; MR1-interacting protein; MRIP-1; spidin
Gene Symbols: Agap3
Molecular weight: 97,965 Da
Basal Isoelectric point: 7.84  Predict pI for various phosphorylation states
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CENTG3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene