PSD4 Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, ARF
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  cell projection; membrane; plasma membrane; ruffle membrane
Molecular Function:  ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; lipid binding
Biological Process:  regulation of ARF protein signal transduction
Reference #:  Q8BLR5 (UniProtKB)
Alt. Names/Synonyms: BC046518; EFA6B; OTTMUSP00000012792; OTTMUSP00000012793; PH and SEC7 domain-containing protein 4; pleckstrin and Sec7 domain containing 4; Pleckstrin homology and SEC7 domain-containing protein 4; Psd4; SEC7 homolog
Gene Symbols: Psd4
Molecular weight: 112,733 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene