Caldesmon Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. Belongs to the caldesmon family. High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  actin cap; actin cytoskeleton; cytoskeleton; cytosol; intracellular membrane-bounded organelle; myofibril; plasma membrane
Molecular Function:  actin binding; calmodulin binding; myosin binding; protein binding; tropomyosin binding
Biological Process:  muscle contraction
Reference #:  Q05682 (UniProtKB)
Alt. Names/Synonyms: CAD; CALD1; Caldesmon; caldesmon 1; CDM; H-CAD; HCAD; L-CAD; LCAD; MGC21352; NAG22; testis secretory sperm-binding protein Li 227n
Gene Symbols: CALD1
Molecular weight: 93,231 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Caldesmon

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein