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PUS10
Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs. Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. Belongs to the pseudouridine synthase Pus10 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 5.4.99.-; Isomerase; RNA processing |
| Chromosomal Location of mouse Ortholog: 11 A3.2|11 |
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Cellular Component:
cytoplasm; mitochondrion; nucleus
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Molecular Function:
isomerase activity; metal ion binding; primary miRNA binding; pseudouridine synthase activity; RNA binding; tRNA pseudouridine synthase activity
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Biological Process:
primary miRNA processing; pseudouridine synthesis; RNA modification; tRNA processing; tRNA pseudouridine synthesis
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Reference #:
Q9D3U0
(UniProtKB)
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Alt. Names/Synonyms: 2810013G11Rik; 4933435A13Rik; AU014648; C77560; Ccdc139; coiled-coil domain containing 139; Coiled-coil domain-containing protein 139; OTTMUSP00000005468; OTTMUSP00000005469; pseudouridylate synthase 10; Psi55 synthase; Pus10; Putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine 55 synthase; tRNA pseudouridine synthase Pus10; tRNA pseudouridylate synthase; tRNA-uridine isomerase
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Gene Symbols: Pus10
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Molecular weight:
59,710 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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