PUS10 Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs. Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. Belongs to the pseudouridine synthase Pus10 family. Note: This description may include information from UniProtKB.
Protein type: EC 5.4.99.-; Isomerase; RNA processing
Chromosomal Location of mouse Ortholog: 11 A3.2|11
Cellular Component:  cytoplasm; mitochondrion; nucleus
Molecular Function:  isomerase activity; metal ion binding; primary miRNA binding; pseudouridine synthase activity; RNA binding; tRNA pseudouridine synthase activity
Biological Process:  primary miRNA processing; pseudouridine synthesis; RNA modification; tRNA processing; tRNA pseudouridine synthesis
Reference #:  Q9D3U0 (UniProtKB)
Alt. Names/Synonyms: 2810013G11Rik; 4933435A13Rik; AU014648; C77560; Ccdc139; coiled-coil domain containing 139; Coiled-coil domain-containing protein 139; OTTMUSP00000005468; OTTMUSP00000005469; pseudouridylate synthase 10; Psi55 synthase; Pus10; Putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine 55 synthase; tRNA pseudouridine synthase Pus10; tRNA pseudouridylate synthase; tRNA-uridine isomerase
Gene Symbols: Pus10
Molecular weight: 59,710 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein