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DENND2A
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rab |
| Chromosomal Location of mouse Ortholog: 6|6 B1 |
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Cellular Component:
actin cytoskeleton; cytoplasm; cytoskeleton
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Molecular Function:
guanyl-nucleotide exchange factor activity
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Biological Process:
protein transport; retrograde transport, endosome to Golgi
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Reference #:
Q8C4S8
(UniProtKB)
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Alt. Names/Synonyms: B930096L08Rik; C130031G22; DEN2A; DENN domain-containing protein 2A; DENN/MADD domain containing 2A; Dennd2a; mKIAA1277; OTTMUSP00000026158
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Gene Symbols: Dennd2a
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Molecular weight:
113,094 Da
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Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
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