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PAP-gamma
Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. Belongs to the poly(A) polymerase family. Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.7.19; Transferase |
| Chromosomal Location of Human Ortholog: 11|11 A3.2 |
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Cellular Component:
cytosol; nuclear body; nucleoplasm; nucleus
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Molecular Function:
ATP binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; polynucleotide adenylyltransferase activity; RNA binding; transferase activity
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Biological Process:
mRNA polyadenylation; mRNA processing; RNA 3'-end processing; RNA polyadenylation
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Reference #:
Q6PCL9
(UniProtKB)
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Alt. Names/Synonyms: 9630006B20Rik; OTTMUSP00000005471; PAP-gamma; PAPOG; Papolg; Poly(A) polymerase gamma; Polynucleotide adenylyltransferase gamma; Signal recognition particle RNA-adenylating enzyme; SRP 3'-adenylating protein; SRP RNA 3'-adenylating enzyme; SRP RNA-adenylating enzyme
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Gene Symbols: Papolg
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Molecular weight:
82,957 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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