RbBP1 DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor). May function as part of an mSin3A repressor complex. Has no intrinsic transcriptional activity. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B. Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 12|12 C2
Cellular Component:  cytosol; nucleoplasm; nucleus; plasma membrane; transcriptional repressor complex
Molecular Function:  DNA binding; transcription regulatory region DNA binding
Biological Process:  cell differentiation; chromatin organization; erythrocyte development; establishment of Sertoli cell barrier; histone H3-K4 trimethylation; histone H3-K9 trimethylation; histone H4-K20 trimethylation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of gene expression by genetic imprinting; regulation of transcription by RNA polymerase II; spermatogenesis
Reference #:  F8VPQ2 (UniProtKB)
Alt. Names/Synonyms: A630009N03; A630067N03Rik; ARI4A; ARID domain-containing protein 4A; Arid4a; AT rich interactive domain 4A (Rbp1 like); AT rich interactive domain 4A (RBP1-like); AT-rich interactive domain 4A (RBP1-like); AT-rich interactive domain-containing protein 4A; MmRBBP1; OTTMUSP00000018775; Rbb; Rbbp1; Rbp1; retinoblastoma binding protein 1; retinoblastoma-binding protein 1
Gene Symbols: Arid4a
Molecular weight: 142,055 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein