POLR2L DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase
Chromosomal Location of mouse Ortholog: 7|7 F5
Cellular Component:  DNA-directed RNA polymerase complex; nucleoplasm; nucleus; RNA polymerase I complex; RNA polymerase II, core complex; RNA polymerase III complex
Molecular Function:  DNA binding; DNA-directed 5'-3' RNA polymerase activity; metal ion binding; zinc ion binding
Biological Process:  DNA-templated transcription; transcription by RNA polymerase I; transcription by RNA polymerase II; tRNA transcription by RNA polymerase III
Reference #:  P62876 (UniProtKB)
Alt. Names/Synonyms: 2510029B14Rik; DNA-directed RNA polymerase III subunit L; DNA-directed RNA polymerases I, II, and III subunit RPABC5; Polr2l; polymerase (RNA) II (DNA directed) polypeptide L; RNA polymerases I, II, and III subunit ABC5; RPAB5; RPB10; RPB10 homolog
Gene Symbols: Polr2l
Molecular weight: 7,645 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below

POLR2L

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene