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DENND4C
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rab; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 4|4 C4 |
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Cellular Component:
cytoplasm; cytoplasmic vesicle; cytosol; Golgi apparatus; insulin-responsive compartment; intracellular membrane-bounded organelle; membrane; plasma membrane; retromer complex
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Molecular Function:
guanyl-nucleotide exchange factor activity
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Biological Process:
cellular response to insulin stimulus; protein localization to plasma membrane; protein transport; regulation of Rab protein signal transduction
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Reference #:
A6H8H2
(UniProtKB)
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Alt. Names/Synonyms: 1700065A05Rik; AA420392; DEN4C; DENN domain-containing protein 4C; DENN/MADD domain containing 4C; Dennd4c; likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)
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Gene Symbols: Dennd4c
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Molecular weight:
211,458 Da
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Basal Isoelectric point:
6
Predict pI for various phosphorylation states
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