DENND4C a cytoplasmic vesicle membrane-associated guanine nucleotide exchange factor (GEF) that activates RAB10, thereby stimulating the delivery of GLUT4 glucose transporter-enriched vesicles to the plasma membrane in response to insulin. Six isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4|4 C4
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; Golgi apparatus; insulin-responsive compartment; intracellular membrane-bounded organelle; membrane; plasma membrane; retromer complex
Molecular Function:  guanyl-nucleotide exchange factor activity; Rab guanyl-nucleotide exchange factor activity
Biological Process:  cellular response to insulin stimulus; protein localization to plasma membrane; protein transport
Reference #:  A6H8H2 (UniProtKB)
Alt. Names/Synonyms: 1700065A05Rik; AA420392; DENN domain-containing protein 4C; DENN/MADD domain containing 4C; Dennd4c; likely ortholog of H. sapiens chromosome 9 open reading frame 55 (C9orf55)
Gene Symbols: Dennd4c
Molecular weight: 211,458 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein