SART1 Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Belongs to the SNU66/SART1 family. Ubiquitously expressed. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 19|19 A
Cellular Component:  Cajal body; catalytic step 2 spliceosome; Golgi apparatus; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex
Biological Process:  maturation of 5S rRNA; mRNA cis splicing, via spliceosome; mRNA processing; mRNA splicing, via spliceosome; positive regulation of cytotoxic T cell differentiation; RNA splicing
Reference #:  Q9Z315 (UniProtKB)
Alt. Names/Synonyms: Haf; Hypoxia-associated factor; mSART-1; SART-1; Sart1; SNUT1; squamous cell carcinoma antigen recognized by T cells 1; Squamous cell carcinoma antigen recognized by T-cells 1; U4/U6.U5 tri-snRNP-associated protein 1; U5-110K
Gene Symbols: Sart1
Molecular weight: 90,885 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene