TOPORS Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 6.3.2.-; EC; Ligase; SUMO conjugating system; SUMO ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 4|4 A5
Cellular Component:  centriole; ciliary basal body; gamma-tubulin complex; nuclear speck; nucleoplasm; nucleus; photoreceptor connecting cilium; PML body; spindle pole; ubiquitin ligase complex
Molecular Function:  antigen binding; DNA binding; DNA topoisomerase binding; metal ion binding; protein binding; SUMO transferase activity; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  cellular response to DNA damage stimulus; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; maintenance of protein location in nucleus; positive regulation of transcription, DNA-templated; positive regulation of ubiquitin-protein transferase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; protein localization to nucleus; protein monoubiquitination; protein polyubiquitination; protein sumoylation; regulation of cell proliferation; ubiquitin-dependent protein catabolic process
Reference #:  Q80Z37 (UniProtKB)
Alt. Names/Synonyms: AW105885; E3 ubiquitin-protein ligase Topors; LUN; OTTMUSP00000006918; p53-binding protein 3; p53BP3; p53BP3/LUN; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; topoisomerase 1-binding RING finger; topoisomerase I binding, arginine/serine-rich; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Topors; TOPRS; TP53BPL; Tumor suppressor p53-binding protein 3
Gene Symbols: Topors
Molecular weight: 117,082 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene