polybromo 1 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. Widely expressed. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Tumor suppressor
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  kinetochore; nucleoplasm; nucleus; RSC-type complex
Molecular Function:  chromatin binding; DNA binding; protein binding
Biological Process:  ATP-dependent chromatin remodeling; blastocyst formation; blood vessel remodeling; cardiac vascular smooth muscle cell development; chromatin organization; chromatin remodeling; epicardium-derived cardiac endothelial cell differentiation; heart development; heart morphogenesis; negative regulation of cell proliferation; nucleosome disassembly; placenta development; positive regulation of transcription, DNA-templated; transcription elongation from RNA polymerase II promoter; vasculogenesis involved in coronary vascular morphogenesis
Reference #:  Q8BSQ9 (UniProtKB)
Alt. Names/Synonyms: 2310032M22Rik; 2610016F04Rik; AI507524; BAF18; BAF180; BRG1-associated factor 180; Pb1; Pbrm1; polybromo 1; Protein polybromo-1
Gene Symbols: Pbrm1
Molecular weight: 187,188 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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polybromo 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene