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POMK
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.183; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Other group; Other-Unique family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 8|8 A2 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; membrane
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Molecular Function:
ATP binding; carbohydrate kinase activity; kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; protein kinase activity; transferase activity
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Biological Process:
brain development; carbohydrate phosphorylation; learning or memory; neuromuscular process; phosphorylation; protein O-linked glycosylation; protein phosphorylation; sensory perception of pain
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Reference #:
Q3TUA9
(UniProtKB)
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Alt. Names/Synonyms: 4930444A02Rik; POMK; probable inactive protein kinase-like protein SgK196; Protein kinase-like protein SgK196; Protein O-mannose kinase; protein-O-mannose kinase; SG196; Sgk19; Sgk196; Sugen kinase 196
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Gene Symbols: Pomk
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Molecular weight:
39,969 Da
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Basal Isoelectric point:
6.14
Predict pI for various phosphorylation states
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