NSUN5 S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. Ubiquitous. Detected in placenta, heart and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.-; Methyltransferase; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 5|5 G2
Cellular Component:  nucleolus; nucleoplasm; nucleus
Molecular Function:  methyltransferase activity; RNA binding; rRNA (cytosine-C5-)-methyltransferase activity; transferase activity
Biological Process:  cerebral cortex development; cognition; corpus callosum development; methylation; oligodendrocyte development; regulation of myelination; RNA methylation; rRNA base methylation; rRNA processing
Reference #:  Q8K4F6 (UniProtKB)
Alt. Names/Synonyms: 28S rRNA (cytosine-C(5))-methyltransferase; 9830109N13Rik; AI326939; NOL1/NOP2/Sun domain family member 5; NOL1/NOP2/Sun domain family, member 5; Nol1r; Nsun5; OTTMUSP00000029049; Probable 28S rRNA (cytosine-C(5))-methyltransferase; Putative methyltransferase NSUN5; Wbscr; Wbscr20; Wbscr20a; Williams Beuren syndrome chromosome region 20A homolog; Williams-Beuren syndrome chromosomal region 20A protein homolog; Williams-Beuren syndrome critical region protein 20
Gene Symbols: Nsun5
Molecular weight: 51,030 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein