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NSUN5
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. Ubiquitous. Detected in placenta, heart and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.1.1.-; Methyltransferase; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 5|5 G2 |
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Cellular Component:
nucleolus; nucleoplasm; nucleus
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Molecular Function:
methyltransferase activity; RNA binding; rRNA (cytosine-C5-)-methyltransferase activity; transferase activity
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Biological Process:
cerebral cortex development; cognition; corpus callosum development; methylation; oligodendrocyte development; regulation of myelination; RNA methylation; rRNA base methylation; rRNA processing
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Reference #:
Q8K4F6
(UniProtKB)
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Alt. Names/Synonyms: 28S rRNA (cytosine-C(5))-methyltransferase; 9830109N13Rik; AI326939; NOL1/NOP2/Sun domain family member 5; NOL1/NOP2/Sun domain family, member 5; Nol1r; Nsun5; OTTMUSP00000029049; Probable 28S rRNA (cytosine-C(5))-methyltransferase; Putative methyltransferase NSUN5; Wbscr; Wbscr20; Wbscr20a; Williams Beuren syndrome chromosome region 20A homolog; Williams-Beuren syndrome chromosomal region 20A protein homolog; Williams-Beuren syndrome critical region protein 20
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Gene Symbols: Nsun5
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Molecular weight:
51,030 Da
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Basal Isoelectric point:
9.33
Predict pI for various phosphorylation states
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