RHOC Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component:  cleavage furrow; cytosol; nucleus; plasma membrane; stereocilium
Molecular Function:  protein binding
Biological Process:  apical junction assembly; G protein-coupled receptor signaling pathway; mitotic cytokinesis; positive regulation of cell migration; positive regulation of lipase activity; positive regulation of protein homooligomerization; positive regulation of stress fiber assembly; regulation of small GTPase mediated signal transduction; skeletal muscle satellite cell migration; wound healing, spreading of cells
Reference #:  P08134 (UniProtKB)
Alt. Names/Synonyms: ARH9; ARHC; epididymis secretory sperm binding protein; h9; MGC1448; MGC61427; oncogene RHO H9; ras homolog family member C; ras homolog gene family, member C; RAS-related homolog 9; Rho cDNA clone 9; Rho-related GTP-binding protein RhoC; RHOC; rhoC GTPase; RHOH9; small GTP binding protein RhoC
Gene Symbols: RHOC
Molecular weight: 22,006 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RHOC

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein