RHOB Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of human Ortholog: 2p24.1
Cellular Component:  cleavage furrow; cytosol; early endosome; endosome membrane; late endosome membrane; nucleus; plasma membrane
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein binding
Biological Process:  angiogenesis; apoptotic process; cell adhesion; cell differentiation; cellular response to hydrogen peroxide; cellular response to ionizing radiation; endosome to lysosome transport; endothelial tube morphogenesis; G protein-coupled receptor signaling pathway; intracellular protein transport; mitotic cytokinesis; negative regulation of cell cycle; negative regulation of cell migration; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of endothelial cell migration; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  P62745 (UniProtKB)
Alt. Names/Synonyms: Aplysia RAS-related homolog 6; ARH6; ARHB; h6; MST081; MSTP081; oncogene RHO H6; ras homolog family member B; ras homolog gene family, member B; Rho cDNA clone 6; Rho-related GTP-binding protein RhoB; RHOB; RHOH6
Gene Symbols: RHOB
Molecular weight: 22,123 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene