PATL1 RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). Belongs to the PAT1 family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Isomerase; RNA-binding
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; nucleus; P-body
Molecular Function:  G-quadruplex RNA binding; poly(G) binding; poly(U) RNA binding; RNA binding; translation repressor activity
Biological Process:  cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; negative regulation of translation
Reference #:  Q3TC46 (UniProtKB)
Alt. Names/Synonyms: AV312086; D430024J04; PAT1-like protein 1; Patl1; protein associated with topoisomerase II homolog 1 (yeast); Protein PAT1 homolog 1
Gene Symbols: Patl1
Molecular weight: 86,770 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PATL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene