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PATL1
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). Belongs to the PAT1 family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Isomerase; RNA-binding |
| Chromosomal Location of Human Ortholog: 19|19 A |
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Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; nucleus; P-body
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Molecular Function:
G-quadruplex RNA binding; poly(G) binding; poly(U) RNA binding; RNA binding; translation repressor activity
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Biological Process:
cytoplasmic mRNA processing body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; negative regulation of translation
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Reference #:
Q3TC46
(UniProtKB)
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Alt. Names/Synonyms: AV312086; D430024J04; PAT1-like protein 1; Patl1; protein associated with topoisomerase II homolog 1 (yeast); Protein PAT1 homolog 1
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Gene Symbols: Patl1
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Molecular weight:
86,770 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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