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FIGNL1
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.-; Hydrolase |
| Chromosomal Location of mouse Ortholog: 11|11 A1 |
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Cellular Component:
cytoplasm; nuclear chromosome; nucleus; perinuclear region of cytoplasm
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Molecular Function:
ATP binding; ATP hydrolysis activity; hydrolase activity; metal ion binding; microtubule severing ATPase activity; nucleotide binding
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Biological Process:
cellular response to ionizing radiation; male meiotic nuclear division; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway; osteoblast differentiation; osteoblast proliferation; regulation of cell cycle; regulation of double-strand break repair via homologous recombination
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Reference #:
Q8BPY9
(UniProtKB)
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Alt. Names/Synonyms: fidgetin-like 1; Fidgetin-like protein 1; FIGL1; Fignl1; OTTMUSP00000005361; OTTMUSP00000005362
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Gene Symbols: Fignl1
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Molecular weight:
74,850 Da
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Basal Isoelectric point:
6.04
Predict pI for various phosphorylation states
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