CCDC79 Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity. Belongs to the TERB1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nuclear envelope
Chromosomal Location of Human Ortholog: 8|8 D3
Cellular Component:  chromosome; chromosome, telomeric region; membrane; nuclear chromosome, telomeric region; nuclear inner membrane; nucleus
Molecular Function:  DNA binding; protein binding
Biological Process:  meiotic attachment of telomere to nuclear envelope; meiotic cell cycle; meiotic telomere clustering; synapsis
Reference #:  Q8C0V1 (UniProtKB)
Alt. Names/Synonyms: 4930532D21Rik; BB085179; CCD79; Ccdc79; coiled-coil domain containing 79; Coiled-coil domain-containing protein 79; telomere repeat binding bouquet formation protein 1; Telomere repeats-binding bouquet formation protein 1; TERB1
Gene Symbols: Terb1
Molecular weight: 86,835 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
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CCDC79

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene