RIC8A Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. Belongs to the synembryn family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.
Chromosomal Location of Human Ortholog: 7|7 F4
Cellular Component:  cytoplasm; cytosol; membrane; plasma membrane
Molecular Function:  G-protein alpha-subunit binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; basement membrane organization; cell migration involved in gastrulation; cell-cell adhesion involved in gastrulation; G protein-coupled receptor signaling pathway; gastrulation; in utero embryonic development; regulation of G protein-coupled receptor signaling pathway; response to light stimulus; vasculature development; visual learning
Reference #:  Q3TIR3 (UniProtKB)
Alt. Names/Synonyms: AI114950; OTTMUSP00000027447; Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog (C. elegans); RIC-8; Ric8; Ric8a; synembryn; Synembryn-A
Gene Symbols: Ric8a
Molecular weight: 59,847 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene