INTS3 Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. Belongs to the Integrator subunit 3 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 3|3 F1
Cellular Component:  cytoplasm; integrator complex; nucleolus; nucleus; SOSS complex
Biological Process:  cellular response to DNA damage stimulus; DNA repair; mitotic cell cycle checkpoint; response to ionizing radiation; snRNA processing
Reference #:  Q7TPD0 (UniProtKB)
Alt. Names/Synonyms: C77668; Int3; Integrator complex subunit 3; Ints3; Sensor of single-strand DNA complex subunit A; Sensor of ssDNA subunit A; SOSS complex subunit A; SOSS-A
Gene Symbols: Ints3
Molecular weight: 117,938 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene