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PALB2
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. Note: This description may include information from UniProtKB.
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| Protein type: Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 7|7 F2 |
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Cellular Component:
DNA repair complex; nuclear speck; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
DNA binding
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Biological Process:
animal organ morphogenesis; apoptotic process; DNA damage response; DNA recombination; DNA repair; double-strand break repair via homologous recombination; embryonic organ development; in utero embryonic development; inner cell mass cell proliferation; mesoderm development; multicellular organism growth; negative regulation of apoptotic process; post-anal tail morphogenesis; somitogenesis
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Reference #:
Q3U0P1
(UniProtKB)
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Alt. Names/Synonyms: 4732427B05; BC066140; OTTMUSP00000025884; Palb2; Partner and localizer of BRCA2
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Gene Symbols: Palb2
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Molecular weight:
119,097 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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