TNRC6C Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of mouse Ortholog: 11|11 E2
Cellular Component:  nucleoplasm; P-body
Molecular Function:  nucleic acid binding; RNA binding
Biological Process:  embryonic hemopoiesis; embryonic organ development; endoderm development; endoderm formation; lung saccule development; miRNA-mediated gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of miRNA-mediated gene silencing; regulation of translation; regulatory ncRNA-mediated gene silencing; transforming growth factor beta receptor signaling pathway
Reference #:  Q3UHC0 (UniProtKB)
Alt. Names/Synonyms: 9930033H14Rik; Kiaa1582; mKIAA1582; OTTMUSP00000003862; TNR6C; Tnrc6c; trinucleotide repeat containing 6C; Trinucleotide repeat-containing gene 6C protein
Gene Symbols: Tnrc6c
Molecular weight: 175,775 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Select Structure to View Below

TNRC6C

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene