p90RSK an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily; Translation
Chromosomal Location of Human Ortholog: 4|4 D2.3
Cellular Component:  cytoplasm; cytosol; nucleus; spindle
Molecular Function:  ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; kinase activity; magnesium ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transcription factor binding; transferase activity
Biological Process:  hepatocyte proliferation; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; phosphorylation; positive regulation of hepatic stellate cell activation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein phosphorylation
Reference #:  P18653 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 1; KS6A1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Mapkapk1a; OTTMUSP00000010160; p90-RSK 1; p90rsk; p90RSK1; p90S6K; Ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal S6 kinase 1; Rps6ka1; rsk; RSK-1; Rsk1; S6K-alpha-1
Gene Symbols: Rps6ka1
Molecular weight: 81,595 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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p90RSK

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene