PRUNE Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. Belongs to the PPase class C family. Prune subfamily. Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component:  cell junction; cytoplasm; cytosol; nucleus
Molecular Function:  exopolyphosphatase activity; hydrolase activity; inorganic diphosphatase activity; metal ion binding; phosphatase activity; pyrophosphatase activity; tubulin binding
Biological Process:  polyphosphate catabolic process; regulation of microtubule polymerization; regulation of neurogenesis
Reference #:  Q8BIW1 (UniProtKB)
Alt. Names/Synonyms: 9230112O05Rik; C130058A12; DRES-17; Exopolyphosphatase PRUNE1; HTCD37; OTTMUSP00000025382; Protein prune homolog; PRUN1; Prune; prune exopolyphosphatase; prune homolog; Prune-M1; Prune1; PRUNEM1
Gene Symbols: Prune1
Molecular weight: 50,240 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene