CTF18
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Belongs to the activator 1 small subunits family. CTF18 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA replication |
Chromosomal Location of mouse Ortholog: 17|17 A3.3 |
Cellular Component:
Ctf18 RFC-like complex; cytoplasm; cytosol; male germ cell nucleus; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; DNA binding; DNA clamp loader activity; nucleotide binding; single-stranded DNA helicase activity
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Biological Process:
cell cycle; chromosome segregation; DNA replication; germ cell development; male meiotic nuclear division; negative regulation of chromosome segregation; positive regulation of DNA-directed DNA polymerase activity; reciprocal meiotic recombination
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Reference #:
Q8BIW9
(UniProtKB)
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Alt. Names/Synonyms: 6030457M03Rik; Chl12; Chl12 homolog; Chromosome transmission fidelity protein 18 homolog; Chtf18; Ctf18; CTF18, chromosome transmission fidelity factor 18; CTF18, chromosome transmission fidelity factor 18 homolog; CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); MGC38008
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Gene Symbols: Chtf18
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Molecular weight:
108,137 Da
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Basal Isoelectric point:
6.36
Predict pI for various phosphorylation states
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