NCAPH2 Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Seems to have lineage-specific role in T-cell development. Belongs to the CND2 H2 (condensin-2 subunit 2) family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 15 E3|15 44.84 cM
Cellular Component:  cell junction; chromosome; condensed chromosome; condensed nuclear chromosome; condensin complex; intercellular bridge; nucleoplasm; nucleus
Molecular Function:  chromatin binding
Biological Process:  chromosome condensation; female meiosis chromosome separation; female meiotic nuclear division; meiotic chromosome condensation; mitotic chromosome condensation; mitotic sister chromatid separation; positive regulation of chromosome segregation; positive regulation of chromosome separation; T cell differentiation in thymus
Reference #:  Q8BSP2 (UniProtKB)
Alt. Names/Synonyms: 0610010J20Rik; 2610524G04Rik; 384D8_6; AI255179; CNDH2; Condensin-2 complex subunit H2; D15Ertd785; D15Ertd785e; Kleisin beta; Kleisin-beta; MGC6766; Ncaph2; Non-SMC condensin II complex subunit H2; non-SMC condensin II complex, subunit H2
Gene Symbols: Ncaph2
Molecular weight: 68,945 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein