NTE Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Belongs to the NTE family. Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8 A1.1|8 1.92 cM
Cellular Component:  endoplasmic reticulum; integral component of membrane; membrane
Molecular Function:  carboxylic ester hydrolase activity; hydrolase activity; lysophospholipase activity
Biological Process:  angiogenesis; animal organ morphogenesis; lipid catabolic process; lipid metabolic process; phosphatidylcholine metabolic process
Reference #:  Q3TRM4 (UniProtKB)
Alt. Names/Synonyms: AI661849; MSws; Neuropathy target esterase; Nte; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; PLPL6; Pnpla6; Swiss cheese; Swiss-cheese
Gene Symbols: Pnpla6
Molecular weight: 149,537 Da
Basal Isoelectric point: 8.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene