NFRKB Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. Belongs to the NFRKB family. Expressed in thymus, brain, testes, spleen and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 9|9 A4
Cellular Component:  Ino80 complex; nucleus
Molecular Function:  DNA binding; protease binding
Biological Process:  cellular response to DNA damage stimulus; DNA recombination; DNA repair
Reference #:  Q6PIJ4 (UniProtKB)
Alt. Names/Synonyms: A530090G11Rik; DNA-binding protein R kappa-B; Nfrkb; nuclear factor related to kappa B binding protein; Nuclear factor related to kappa-B-binding protein
Gene Symbols: Nfrkb
Molecular weight: 138,764 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
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NFRKB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene