NFRKB Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. Belongs to the NFRKB family. Expressed in thymus, brain, testes, spleen and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of mouse Ortholog: 9|9 A4
Cellular Component:  Ino80 complex; nucleoplasm; nucleus
Molecular Function:  DNA binding; protease binding
Biological Process:  cellular response to DNA damage stimulus; chromatin remodeling; DNA recombination; DNA repair; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of telomere maintenance in response to DNA damage; regulation of cell cycle; regulation of chromosome organization; regulation of DNA repair; regulation of DNA replication; regulation of DNA strand elongation; regulation of embryonic development; telomere maintenance
Reference #:  Q6PIJ4 (UniProtKB)
Alt. Names/Synonyms: A530090G11Rik; DNA-binding protein R kappa-B; Nfrkb; nuclear factor related to kappa B binding protein; Nuclear factor related to kappa-B-binding protein
Gene Symbols: Nfrkb
Molecular weight: 138,764 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene