ASCC3 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10|10 B3
Cellular Component:  activating signal cointegrator 1 complex; cytosol; nucleus
Molecular Function:  ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent helicase activity; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding
Biological Process:  cell proliferation; cellular response to DNA damage stimulus; DNA dealkylation involved in DNA repair; DNA duplex unwinding; DNA repair
Reference #:  E9PZJ8 (UniProtKB)
Alt. Names/Synonyms: Activating signal cointegrator 1 complex subunit 3; ASC1p; ASC1p200; Ascc3; Ascc3 protein; B630009I04Rik; BC023451; D430001L07Rik; D630041L21; Heli; Helic1; helicase, ATP binding 1; RNAH
Gene Symbols: Ascc3
Molecular weight: 250,557 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene