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ASCC3
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. Belongs to the helicase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.12; Helicase; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 10|10 B3 |
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Cellular Component:
activating signal cointegrator 1 complex; cytosol; intracellular; nucleus
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Molecular Function:
ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent helicase activity; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding
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Biological Process:
cell proliferation; cellular response to DNA damage stimulus; DNA dealkylation involved in DNA repair; DNA duplex unwinding; DNA repair; regulation of transcription, DNA-templated; transcription, DNA-dependent
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Reference #:
E9PZJ8
(UniProtKB)
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Alt. Names/Synonyms: Activating signal cointegrator 1 complex subunit 3; ASC1p200; Ascc3; Ascc3 protein; B630009I04Rik; BC023451; D430001L07Rik; D630041L21; Helic1; helicase, ATP binding 1; RNAH
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Gene Symbols: Ascc3
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Molecular weight:
250,557 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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