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Nlp
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Microtubule-binding |
| Chromosomal Location of mouse Ortholog: 2|2 G3 |
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Cellular Component:
centrosome; cytoplasm; cytoskeleton; cytosol; intercellular bridge; microtubule; microtubule cytoskeleton
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Molecular Function:
calcium ion binding; metal ion binding
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Biological Process:
microtubule anchoring at centrosome
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Reference #:
Q6ZQ12
(UniProtKB)
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Alt. Names/Synonyms: 4930519N13Rik; Gm1004; Gm1634; Kiaa0980; mKIAA0980; ninein-like; Ninein-like protein; Ninl; Nlp
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Gene Symbols: Ninl
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Molecular weight:
157,838 Da
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Basal Isoelectric point:
4.97
Predict pI for various phosphorylation states
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