Nlp Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of mouse Ortholog: 2|2 G3
Cellular Component:  centrosome; cytoplasm; cytoskeleton; cytosol; intercellular bridge; microtubule
Molecular Function:  calcium ion binding; metal ion binding
Biological Process:  microtubule anchoring at centrosome
Reference #:  Q6ZQ12 (UniProtKB)
Alt. Names/Synonyms: 4930519N13Rik; Gm1004; Gm1634; Kiaa0980; mKIAA0980; ninein-like; Ninein-like protein; Ninl; Nlp
Gene Symbols: Ninl
Molecular weight: 157,838 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene