|
FANCI
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; DNA repair, damage |
| Chromosomal Location of mouse Ortholog: 7|7 D2 |
|
Cellular Component:
cytoplasm; cytosol; DNA repair complex; Fanconi anaemia nuclear complex; nucleoplasm; nucleus
|
|
Molecular Function:
DNA polymerase binding
|
|
Biological Process:
cell cycle; DNA damage response; DNA repair; positive regulation of protein ubiquitination
|
|
Reference #:
Q8K368
(UniProtKB)
|
|
Alt. Names/Synonyms: Fanci; Fanconi anemia group I protein homolog; Fanconi anemia, complementation group I; MGC38195; MGC38407; Protein FACI
|
|
Gene Symbols: Fanci
|
|
Molecular weight:
149,326 Da
|
|
Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
|
