WNK2 Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Wnk family
Chromosomal Location of mouse Ortholog: 13 A5|13 25.07 cM
Cellular Component:  cytoplasm; cytosol; membrane; plasma membrane
Molecular Function:  ATP binding; chloride channel inhibitor activity; kinase activity; nucleotide binding; potassium channel inhibitor activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  intracellular signal transduction; ion homeostasis; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of sodium ion transport; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of ion transmembrane transporter activity; positive regulation of potassium ion import; positive regulation of sodium ion transmembrane transporter activity; protein autophosphorylation; protein phosphorylation
Reference #:  Q3UH66 (UniProtKB)
Alt. Names/Synonyms: 1810073P09Rik; AW122246; ESTM1; ESTM15; Kiaa1760; mKIAA1760; Protein kinase lysine-deficient 2; Protein kinase with no lysine 2; Serine/threonine-protein kinase WNK2; WNK lysine deficient protein kinase 2; Wnk2; X83337
Gene Symbols: Wnk2
Molecular weight: 227,527 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein