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SPRY3
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Widely expressed; particularly in the fetal tissues. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: - |
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Cellular Component:
cytoplasm; cytosol; membrane
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Molecular Function:
protein binding
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Biological Process:
animal organ development; multicellular organism development; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of neuron projection arborization; negative regulation of Ras protein signal transduction; nervous system development; regulation of signal transduction
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Reference #:
Q3UUD2
(UniProtKB)
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Alt. Names/Synonyms: Gm1409; Gm391; MCG113144; Protein sprouty homolog 3; spro; sprouty homolog 3; Sprouty homolog 3 (Drosophila); sprouty RTK signaling antagonist 3; sprouty3; Spry-3; Spry3
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Gene Symbols: Spry3
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Molecular weight:
31,363 Da
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Basal Isoelectric point:
7.39
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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